Green versatile micellar electrokinetic chromatographic method for determination of six antimicrobial and anti-inflammatory drugs in combined dosage forms

Abstract A fast reliable micellar electrokinetic methodology was investigated for the concurrent quantitation of six antimicrobial and anti-inflammatory drugs, namely, ciprofloxacin, dexamethasone, metronidazole, ornidazole, spiramycin tinidazole. The method has merits rapidity, precision, sensitivity. separation carried out in less than 7 min by applying a basic background electrolyte consisting 25 mM disodium tetraborate buffer, pH 9 containing 50 SDS at kV using photodiode array detector 230 315 nm. internal standard used during analysis cromolyn sodium validation following ICH guidelines. proposed showed linear response over range from 0.5 to 10.0 μg mL −1 reaching limits detection ranges 0.09–0.2 0. 27–0.6 respectively. method's greenness estimated GAPI tool where excellent concluded. Co-formulated or single-ingredient commercial preparations were results statistically evaluated.